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Degenerative Disorders Of The Brain


Degenerative Disorders Of The Brain
Author: Darren R. Hocking
Publisher: Routledge
ISBN: 1351208896
Size: 21.21 MB
Format: PDF, Docs
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Covering a wide range of diverse age-related disorders, Degenerative Disorders of the Brain addresses disabilities that occur or have their roots in the later stages of life. The book brings together an internationally recognised group of contributors to discuss frontostriatal, fronto-cerebellar and other major brain systems and structures which control and direct normal behaviour, and which can fail during the aging process, as well as addressing behavioural, clinical, pathophysiological and technical aspects. Discussing the latest clinical and behavioural findings of disorders which are largely, though not necessarily entirely, age related, including Alzheimer’s disease and other dementias, Parkinson’s disease and related disorders, and Huntington’s disease, the book covers information vital to the understanding, diagnosis, and management of degenerative disorders of the brain. It also considers the role of epigenetics, neural plasticity, and environmental enrichment in neurodegenerative disorders alongside the role of ground-breaking intervention methods, including transcranial magnetic stimulation and deep brain stimulation. Degenerative Disorders of the Brain will be of great interest to, and use for, clinicians, researchers, students, lecturers, and affected individuals and their relatives.




From Development To Degeneration And Regeneration Of The Nervous System


Degenerative Disorders Of The Brain
Author: Charles E. Ribak PhD
Publisher: Oxford University Press
ISBN: 0195369009
Size: 48.49 MB
Format: PDF, Mobi
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This book provides current information about the three areas mentioned in the title: Neuronal Migration and Development, Degenerative Brain Diseases, and Neural Plasticity and Regeneration. The chapters about brain development examine the cellular and molecular mechanisms by which neurons are generated from the ventricular zone in the forebrain and migrate to their destinations in the cerebral cortext. This description of cortical development also includes a discussions of the Cajal-Retzius cell. Another chapter provides insight about the development of another forebrain region, the hypothalamus. The remaining chapters of this section examine the clinical relevance of brain development in certain disease states in humans: neural tube defects and the normal and abnormal development of human electroencephalographic recordings during the first year of age.The second section on degenerative disorders of the brain begins wtih details about the dopaminergic neurons in the substantia niger and their loss in Parkinson's disease. Two subsequent chapters describe changes in brain aging, including changes in the numbers of myelinated axons. Other chapters in this section describe important cellular and molecular changes found in Alzheimer's disease and human epilepsy. Together, these chapters summarize much of our current knowledge about the major molecular and cellular changes found in several degenerative diseases of the brain.The last section addresses the issues of brain plasticity and regeneration in the adult brain and begins with a chapter on how the brain's own stem cells provide newly generated neurons to the hippocampal dentate gyrus and how these neurons become integrated into neural circuitry. The following two chapters examine some of the neuroplastic changes that take place in motor and sensory cortices of awake behaving primates. The concluding two chapters address the issue of regeneration in the injured spinal cord and the factors that may contribute to its success.




Degenerative Diseases Of The Brain


Degenerative Disorders Of The Brain
Author: Igor Tabrizian
Publisher:
ISBN: 9780975692073
Size: 15.13 MB
Format: PDF, ePub, Mobi
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The lecture looks at the nutritional aspect of normal brain function as the current models of Neurodegenative disorders.




Innate Immunity And Neurodegenerative Disorders


Degenerative Disorders Of The Brain
Author: Roger A Barker
Publisher: Frontiers E-books
ISBN: 2889193101
Size: 15.63 MB
Format: PDF, Kindle
View: 5720
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Inflammation of the brain in the context of neurodegenerative disorders is an area of intense debate and discussion, not least in terms of its pathogenic significance and the extent to which it drives disease processes and pathology. This inflammation can take several forms including innate responses recruiting microglia, humoral responses involving antibody, complement mediated processes and cellular T-cell activation, of which the role and extent of each may differ between diseases. Whilst some diseases have been more intensely linked to inflammation and long-term degeneration (e.g. MS), more traditional chronic neurodegenerative disorders have been thought of in terms of intrinsic neuronal pathology with a secondary innate response. However, it has been described that microglia activation is an early event of many degenerative disorders and evidence is accumulating that it may play a critical role in actually causing pathology and driving disease processes. If true, this would have major therapeutic implications, but what is the evidence that this is the case? The initial observations by Patrick McGeer’s group of post-mortem tissue from patients with Parkinson’s disease revealed the presence of activated brain microglia and has thus lead to the hypothesis that chronic inflammation could participate to neuronal degenerative processes. The significance of these original observations has only been recently revisited, and the development of more powerful tools to study the brain immune response has certainly contributed to this field of research. Chronic inflammation in the brain can take many forms but of particular interest has been the resident microglia and the role they play in this process. In this context, microglia have often been thought to become activated only after the disease has begun and then to contribute minimally to the degenerative process. Emerging new concepts challenge this view by proposing that microglial senescence, for example, may release the disease process and/or accelerate it. In addition, microglia, once activated, can adopt different phenotypes which can be both pro-inflammatory and pro-repair and may impact not only on the healthy adult neuronal population but on those new neurons derived from neurogenic niches of the adult brain. In this Research Topic, we attempt to explore this by first considering the innate immune responses in the brain and the methods by which they can be studied experimentally and in patients with various neurodegenerative disorders. This sets the scene for then discussing a range of different disorders including Alzheimer’s, Parkinson’s, Huntington’s disease and amyotrophic lateral sclerosis. These papers seek to discuss the evidence for an innate immune response and whether this is beneficial or detrimental, as well as its therapeutic implications.




Progressive Brain Disorders In Childhood


Degenerative Disorders Of The Brain
Author: Juan M. Pascual
Publisher: Cambridge University Press
ISBN: 1107042054
Size: 21.36 MB
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A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.



Degenerative Disorders of the Brain
Language: en
Pages: 266
Authors: Darren R. Hocking, John L. Bradshaw, Joanne Fielding
Categories: Psychology
Type: BOOK - Published: 2019-04-05 - Publisher: Routledge
Covering a wide range of diverse age-related disorders, Degenerative Disorders of the Brain addresses disabilities that occur or have their roots in the later stages of life. The book brings together an internationally recognised group of contributors to discuss frontostriatal, fronto-cerebellar and other major brain systems and structures which control
From Development to Degeneration and Regeneration of the Nervous System
Language: en
Pages: 343
Authors: Charles E. Ribak PhD, Carlos Aramburo de la Hoz Phd, Edward G. Jones, PhD, Jorge A. Larriva Sahd, PhD, Larry W. Swanson PhD
Categories: Medical
Type: BOOK - Published: 2009 - Publisher: Oxford University Press
This book provides current information about the three areas mentioned in the title: Neuronal Migration and Development, Degenerative Brain Diseases, and Neural Plasticity and Regeneration. The chapters about brain development examine the cellular and molecular mechanisms by which neurons are generated from the ventricular zone in the forebrain and migrate
Innate immunity and neurodegenerative disorders
Language: en
Pages:
Authors: Roger A Barker, Francesca Cicchetti
Categories: Medical
Type: BOOK - Published: 2014-11-03 - Publisher: Frontiers E-books
Inflammation of the brain in the context of neurodegenerative disorders is an area of intense debate and discussion, not least in terms of its pathogenic significance and the extent to which it drives disease processes and pathology. This inflammation can take several forms including innate responses recruiting microglia, humoral responses
Brain Disorders Sourcebook
Language: en
Pages: 657
Authors: Joyce Brennfleck Shannon
Categories: Health & Fitness
Type: BOOK - Published: 2010 - Publisher: Omnigraphics Incorporated
Basic consumer health information about acquired and traumatic brain injuries, infections of the brain, epilepsy and seizure disorders, cerebral palsy, and degenerative neurological disorders.
Free Radicals in the Brain
Language: en
Pages: 186
Authors: Lester Packer, Leonid Prilipko
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media
Free radicals appear to play a mojor role in many neurological (and non neurological) dieseases. Both acute and degenerative disorders are thought to involve free radicals reactions in tissue injury (for a list see this book page 18). This issue is very important for basic science and for therapeuthic approach